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Adherence measurement

Medication adherence: a healthcare blind spot we can measure better

A treatment plan can be visible in the clinical record while day-to-day implementation remains unclear. Better adherence measurement begins by defining the phase, signal, denominator, timeframe, and uncertainty.

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The plan is visible; implementation often is not

A prescription records what should happen. It does not by itself show whether treatment started, how it was followed each day, or when it stopped. Those are different phases and should not be compressed into one unexplained percentage.

Each data source answers a different question

A pharmacy refill suggests supply, self-report adds personal context, and an electronic event adds timing. None is automatically proof of correct ingestion, and each measure needs a clear denominator and observation period.

An opening is an opening, a refill is a supply event, and a recorded status is a recorded status.

Swiss research compares practical measurement signals

University of Basel researchers have compared dispensing data with electronic monitoring in a small anticoagulant study population. Geneva and Lausanne teams have used electronic records inside interprofessional adherence programs. These studies add measurement insight, not population-wide certainty.

Monitoring is useful when it supports feedback

Research suggests electronic-monitoring feedback may help in some settings, while clinical-outcome evidence remains uncertain. The purpose should be a better, non-judgmental conversation—not automatic treatment decisions or constant surveillance.

Adherlo can add visibility without claiming certainty

Adherlo supports schedules, reminders, taken-or-skipped records, history, and optional Smart Pillbox events. These signals can support review; they do not establish ingestion, adherence outcomes, or clinical benefit.

Sources used in this guide

These references provide context for medication safety, adherence workflows, and the healthcare settings discussed here. They are not Adherlo outcome claims.

Global · peer-reviewed · 2012

A new taxonomy for describing and defining adherence to medications

Peer-reviewed taxonomy defining initiation, implementation, and discontinuation to make adherence terminology more precise.

Open source

Global · guideline · 2018

ESPACOMP Medication Adherence Reporting Guideline (EMERGE)

Peer-reviewed reporting guideline for consistent medication-adherence concepts, measurement, analysis, and reporting.

Open source

Global · peer-reviewed · 2020

How the EMERGE guideline can improve clinical trials

Peer-reviewed discussion of adherence measurement, analysis, and interpretation in clinical trials; not evidence for a specific monitoring product.

Open source

Switzerland · peer-reviewed · 2024

Concordance between dispensing and electronic adherence monitoring

Swiss secondary analysis comparing pharmacy dispensing with electronic monitoring in a small anticoagulant study population; useful for measurement context, not population-wide conclusions.

Open source

Switzerland · peer-reviewed · 2022

Medication adherence evaluated through electronic monitors in Switzerland

Longitudinal Swiss analysis using electronic-container openings as an implementation proxy in 118 supported patients; the records do not confirm ingestion and are not nationally representative.

Open source

Related resources

See how Adherlo records medication routines

Explore the Adherlo App for schedules, reminders, and reviewable intake history, or learn how the optional Smart Pillbox adds physical cues and event records.